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Evidence found and GRADE certainty

14 questions · 14 findings · 2 reviews · Musculoskeletal

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No studies found 0 · 0%GRADE not reported 1 · 7.1%Very low 3 · 21.4%Low 4 · 28.6%Moderate 6 · 42.9%High 0 · 0%

Celecoxib vs tNSAIDs

Number withdrawn due to adverse events · patients with osteoarthritis

Celecoxib showed no clear difference in number withdrawn due to adverse events compared with tNSAIDs (low certainty).

1 finding from 1 review

Celecoxib vs tNSAIDs

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing any serious adverse events compared with tNSAIDs (very low certainty).

1 finding from 1 review

Celecoxib vs tNSAIDs

Number experiencing gastro‐intestinal events (perforation, ulcer, bleeds) · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing gastro‐intestinal events (perforation, ulcer,… compared with tNSAIDs (very low certainty).

1 finding from 1 review

Celecoxib vs tNSAIDs

Cardiovascular events (myocardial infarction, stroke) · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing cardiovascular events (myocardial infarction,… compared with tNSAIDs (very low certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Cardiovascular events (myocardial infarction, stroke) · patients with rheumatoid arthritis

Celecoxib showed no clear difference in cardiovascular events (myocardial infarction, stroke) compared with traditional NSAIDs (low certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Incidence of gastroduodenal ulcers ≥ 3 mm · patients with rheumatoid arthritis

Celecoxib probably leads to lower incidence of gastroduodenal ulcers ≥ 3 mm compared with traditional NSAIDs (moderate certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Short‐term serious adverse events · patients with rheumatoid arthritis

Celecoxib showed no clear difference in short‐term serious adverse events compared with traditional NSAIDs (low certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Total number of withdrawals · patients with rheumatoid arthritis

Celecoxib probably leads to lower total withdrawals; compared with traditional NSAIDs (moderate certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Clinical improvement: American College of Rheumatology 20% improvement criteria (ACR20) · patients with rheumatoid arthritis

Celecoxib showed no clear difference in clinical improvement: American College of Rheumatology 20%… compared with traditional NSAIDs (moderate certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Pain A 0 t o 100 visual or numerical scale, where 0 equals no pain at all and 100 is the worst pain imaginable · patients with rheumatoid arthritis
1 finding from 1 review