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What do systematic reviews say?

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Evidence found and GRADE certainty

48 questions · 48 findings · 7 reviews

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No studies found 8 · 16.7%GRADE not reported 8 · 16.7%Very low 8 · 16.7%Low 13 · 27.1%Moderate 9 · 18.8%High 2 · 4.2%

Celecoxib vs tNSAIDs

Number withdrawn due to adverse events · patients with osteoarthritis

Celecoxib showed no clear difference in number withdrawn due to adverse events compared with tNSAIDs (low certainty).

1 finding from 1 review

Celecoxib vs tNSAIDs

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing any serious adverse events compared with tNSAIDs (very low certainty).

1 finding from 1 review

Celecoxib vs tNSAIDs

Number experiencing gastro‐intestinal events (perforation, ulcer, bleeds) · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing gastro‐intestinal events (perforation, ulcer,… compared with tNSAIDs (very low certainty).

1 finding from 1 review

Celecoxib vs tNSAIDs

Cardiovascular events (myocardial infarction, stroke) · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing cardiovascular events (myocardial infarction,… compared with tNSAIDs (very low certainty).

1 finding from 1 review

Celecoxib vs placebo

Number withdrawn due to adverse events · patients with osteoarthritis

Celecoxib showed no clear difference in number withdrawn due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Celecoxib vs placebo

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing any serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

Celecoxib vs placebo

Number experiencing gastro‐intestinal events (perforation, ulcer, bleeds) · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing gastro‐intestinal events (perforation, ulcer,… compared with placebo (very low certainty).

1 finding from 1 review

Celecoxib vs placebo

Cardiovascular events (myocardial infarction, stroke) · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing cardiovascular events (myocardial infarction,… compared with placebo (very low certainty).

1 finding from 1 review

Celecoxib vs placebo

Clinical improvement: American College of Rheumatology 20% improvement criteria (ACR20) · patients with rheumatoid arthritis

Celecoxib probably leads to higher clinical improvement: American College of Rheumatology 20%… compared with placebo (moderate certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Cardiovascular events (myocardial infarction, stroke) · patients with rheumatoid arthritis

Celecoxib showed no clear difference in cardiovascular events (myocardial infarction, stroke) compared with traditional NSAIDs (low certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Incidence of gastroduodenal ulcers ≥ 3 mm · patients with rheumatoid arthritis

Celecoxib probably leads to lower incidence of gastroduodenal ulcers ≥ 3 mm compared with traditional NSAIDs (moderate certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Short‐term serious adverse events · patients with rheumatoid arthritis

Celecoxib showed no clear difference in short‐term serious adverse events compared with traditional NSAIDs (low certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Total number of withdrawals · patients with rheumatoid arthritis

Celecoxib probably leads to lower total withdrawals; compared with traditional NSAIDs (moderate certainty).

1 finding from 1 review