Findings

What do systematic reviews say?

5 questions · 5 findings · 4 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 40%Low 3 · 60%Moderate 0 · 0%High 0 · 0%

Gastrointestinal adverse events · older people with age‐related memory loss

NSAIDs (celecoxib) may leads to higher adverse events – gastrointestinal compared with placebo (low certainty).

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
RR 2.66 [1.05, 6.75]
1 study · 40 participants
Low

Short‐term serious adverse events · patients with rheumatoid arthritis

Celecoxib showed no clear difference in short‐term serious adverse events compared with traditional NSAIDs (low certainty).

1 finding from 1 review

Celecoxib for rheumatoid arthritis 2017 · Cochrane Headline outcomes only
Peto OR 0.71 [0.39, 1.28]
5 studies · 2154 participants
Low

Number withdrawn due to adverse events · patients with osteoarthritis

Celecoxib showed no clear difference in number withdrawn due to adverse events compared with tNSAIDs (low certainty).

1 finding from 1 review

Celecoxib for osteoarthritis 2017 · Cochrane Headline outcomes only
Peto OR 0.97 [0.74, 1.27]
8 studies · 3150 participants
Low

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing any serious adverse events compared with tNSAIDs (very low certainty).

1 finding from 1 review

Celecoxib for osteoarthritis 2017 · Cochrane Headline outcomes only
Peto OR 0.92 [0.66, 1.28]
5 studies · 2404 participants
Very low

Withdrawals due to adverse events · children and adolescents with chronic non‐cancer pain

1 finding from 1 review