Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

7 questions · 7 findings · 1 reviews · Acute Respiratory Infections

No studies found 0 · 0%GRADE not reported 1 · 14.3%Very low 1 · 14.3%Low 1 · 14.3%Moderate 4 · 57.1%High 0 · 0%

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Death ‐ in all participants ‐ short term · people suspected to have meningococcal disease (adults and children)

Ceftriaxone showed no clear difference in death ‐ in all participants ‐ short term compared with long‐acting (oily) chloramphenicol (moderate certainty).

1 finding from 1 review

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Death ‐ in confirmed cases of meningococcal meningitis (subgroup) · people suspected to have meningococcal disease (adults and children)

Ceftriaxone showed no clear difference in death ‐ in confirmed cases of meningococcal meningitis (subgroup) compared with long‐acting (oily) chloramphenicol (moderate certainty).

1 finding from 1 review

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Clinical failure ‐ in all participants ‐ short term Composite clinical criteria10 · people suspected to have meningococcal disease (adults and children)

Ceftriaxone showed no clear difference in clinical failure ‐ in all participants ‐ short term Composite… compared with long‐acting (oily) chloramphenicol (moderate certainty).

1 finding from 1 review

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Clinical failure ‐ in confirmed cases of meningococcal meningitis (subgroup) Composite clinical criteria10 · people suspected to have meningococcal disease (adults and children)

Ceftriaxone showed no clear difference in clinical failure ‐ in confirmed cases of meningococcal meningitis… compared with long‐acting (oily) chloramphenicol (moderate certainty).

1 finding from 1 review

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Neurological sequelae ‐ in all participants‐ short term Clinical assessment11 · people suspected to have meningococcal disease (adults and children)

Ceftriaxone showed no clear difference in neurological sequelae ‐ in all participants‐ short term Clinical… compared with long‐acting (oily) chloramphenicol (low certainty).

1 finding from 1 review

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Neurological sequelae ‐ in confirmed cases of meningococcal meningitis (subgroup) Clinical assesment11 · people suspected to have meningococcal disease (adults and children)

It is very uncertain whether ceftriaxone changes neurological sequelae ‐ in confirmed cases of meningococcal… compared with long‐acting (oily) chloramphenicol (very low certainty).

1 finding from 1 review