Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

8 questions · 11 findings · 2 reviews

No studies found 5 · 45.5%GRADE not reported 0 · 0%Very low 2 · 18.2%Low 3 · 27.3%Moderate 0 · 0%High 1 · 9.1%

Casirivimab/imdevimab vs placebo

Adverse events: grade 1 to 2 · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

The review found no eligible studies for this question.

2 findings from 1 review

Casirivimab/imdevimab vs placebo

Serious adverse events within 6 months · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

It is very uncertain whether casirivimab/imdevimab changes serious adverse events within 6 months compared with placebo (very low certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Adverse events: all grades · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab showed no clear difference in adverse events: all grades within 6 months compared with placebo (low certainty).

2 findings from 1 review

Casirivimab/imdevimab vs placebo

Serious adverse events until data cut‐offb · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab showed no clear difference in serious adverse events until data cut‐offb compared with placebo (low certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Grades 3 and 4 adverse events · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

It is very uncertain whether casirivimab/imdevimab changes adverse events: grade 3 to 4 within 6 months compared with placebo (very low certainty).

2 findings from 1 review