Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

MMP-2 presence/activity · Human ex vivo carious dentin (mostly coronal), natural caries lesions

MMP-2 may be increased in carious dentin compared with sound dentin, but the evidence is very uncertain (very low certainty).

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
Ex vivo (extracted teeth / clinical carious or biofilm samples)
MMP-2 may be increased in carious dentin when compared to sound dentin, but the evidence is very uncertain.
7 studies · 373 participants
Very low

MMP-2 presence/activity · Human coronal carious dentin and sound dentin

MMP-2 may be increased in carious dentin compared with sound dentin (very low certainty).

1 finding from 1 review

MMP-2 presence/activity · Human ex vivo carious dentin

MMP-2 shows no difference between root and coronal carious dentin; the evidence is very uncertain (very low certainty).

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
Ex vivo (extracted teeth / clinical carious or biofilm samples)
There is no difference in MMP-2 activity in root vs. coronal carious dentin; MMP-2 was present in both coronal and root dentin in all specimens (Toledano et al., 2010). The evidence is very uncertain.
1 study · 10 participants
Very low