Calcium phosphate agent (e.g., CPP-ACP, Ca/P-PILP, niobophosphate) vs No biomimetic remineralization (control)
In the Self-Etch adhesive + chemical ACAD protocol network, Calcium Phosphate vs Control showed no significant difference in 24 h bond strength (MD 1.539, 95% CI -1.738 to 4.817; Moderate certainty).
- Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. 2025 All outcomes24 h (immediate) · In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS) · Self-Etch + chemical ACADMD 1.539 [-1.738, 4.817]1 studyModerate