Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 50%Moderate 3 · 50%High 0 · 0%

Calcineurin inhibitor (CNI) withdrawal vs standard dose CNI

Graft loss · kidney transplant recipients

Calcineurin inhibitor (CNI) withdrawal may leads to lower graft loss compared with standard dose CNI (low certainty).

1 finding from 1 review

Calcineurin inhibitor withdrawal or tapering for kidney transplant recipients 2017 · Cochrane Headline outcomes only
RR 0.85 [0.74, 0.98]
16 studies · 2090 participants
Low

Calcineurin inhibitor (CNI) withdrawal + mammalian target of rapamycin inhibitor (mTORi) vs standard dose CNI

Graft loss · kidney transplant recipients

Calcineurin inhibitor (CNI) withdrawal + mammalian target of… showed no clear difference in graft loss compared with standard dose CNI (low certainty).

1 finding from 1 review

Calcineurin inhibitor withdrawal or tapering for kidney transplant recipients 2017 · Cochrane Headline outcomes only
RR 0.94 [0.75, 1.19]
25 studies · 5446 participants
Low

Calcineurin inhibitor (CNI) avoidance and late CNI withdrawal vs standard dose CNI

Graft loss: avoidance · kidney transplant recipients

Calcineurin inhibitor (CNI) avoidance and late CNI withdrawal showed no clear difference in graft loss: avoidance compared with standard dose CNI (low certainty).

1 finding from 1 review

Calcineurin inhibitor withdrawal or tapering for kidney transplant recipients 2017 · Cochrane Headline outcomes only
RR 0.96 [0.79, 1.16]
4 studies · 566 participants
Low

Calcineurin inhibitor (CNI) avoidance and late CNI withdrawal vs standard dose CNI

Graft loss: late withdrawal · kidney transplant recipients

Calcineurin inhibitor (CNI) avoidance and late CNI withdrawal probably leads to lower graft loss: late withdrawal compared with standard dose CNI (moderate certainty).

1 finding from 1 review

Calcineurin inhibitor withdrawal or tapering for kidney transplant recipients 2017 · Cochrane Headline outcomes only
RR 0.84 [0.72, 0.97]
13 studies · 1831 participants
Moderate

Calcineurin inhibitor (CNI) avoidance and late withdrawal with mammalian target of rapamycin inhibitor (mTORi) vs standard dose CNI

Graft loss: avoidance · kidney transplant recipients

Calcineurin inhibitor (CNI) avoidance and late withdrawal with… showed no clear difference in graft loss: avoidance compared with standard dose CNI (moderate certainty).

1 finding from 1 review

Calcineurin inhibitor withdrawal or tapering for kidney transplant recipients 2017 · Cochrane Headline outcomes only
RR 1.03 [0.72, 1.48]
8 studies · 1420 participants
Moderate

Calcineurin inhibitor (CNI) avoidance and late withdrawal with mammalian target of rapamycin inhibitor (mTORi) vs standard dose CNI

Graft loss: late withdrawal · kidney transplant recipients

Calcineurin inhibitor (CNI) avoidance and late withdrawal with… showed no clear difference in graft loss: late withdrawal compared with standard dose CNI (moderate certainty).

1 finding from 1 review

Calcineurin inhibitor withdrawal or tapering for kidney transplant recipients 2017 · Cochrane Headline outcomes only
RR 0.92 [0.65, 1.3]
17 studies · 4026 participants
Moderate