Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

80 questions · 80 findings · 5 reviews · Kidney and Transplant

No studies found 4 · 5%GRADE not reported 0 · 0%Very low 17 · 21.3%Low 32 · 40%Moderate 27 · 33.8%High 0 · 0%

Calcineurin inhibitor vs IV cyclophosphamide

Adverse events: treatment failure (non response, serious infection, persistently elevated creatinine) at 6 months · idiopathic steroid‐resistant nephrotic syndrome in children

Calcineurin inhibitor probably leads to lower adverse events: treatment failure at 6 months (non response, serious… compared with IV cyclophosphamide (moderate certainty).

1 finding from 1 review

Calcineurin inhibitor vs IV cyclophosphamide

Discontinuation of medication due to adverse events · idiopathic steroid‐resistant nephrotic syndrome in children

Calcineurin inhibitor probably leads to lower adverse events: medications ceased due to adverse events compared with IV cyclophosphamide (moderate certainty).

1 finding from 1 review