Low dose calcineurin inhibitors (CNI) showed no clear difference in death compared with to standard dose CNI (moderate certainty).
Low dose calcineurin inhibitors (CNI) showed no clear difference in acute rejection compared with to standard dose CNI (moderate certainty).
Calcineurin inhibitor (CNI) withdrawal showed no clear difference in death compared with standard dose CNI (moderate certainty).
Calcineurin inhibitor (CNI) withdrawal probably leads to higher acute rejection compared with standard dose CNI (moderate certainty).
Calcineurin inhibitor (CNI) withdrawal may leads to lower graft loss compared with standard dose CNI (low certainty).
Calcineurin inhibitor (CNI) withdrawal may leads to lower adverse events: hypertension compared with standard dose CNI (low certainty).
Calcineurin inhibitor (CNI) withdrawal showed no clear difference in adverse events: CMV infection compared with standard dose CNI (low certainty).
Calcineurin inhibitor (CNI) withdrawal showed no clear difference in adverse events: malignancy compared with standard dose CNI (low certainty).
Calcineurin inhibitor (CNI) avoidance and late CNI withdrawal showed no clear difference in acute rejection: avoidance compared with standard dose CNI (low certainty).
Calcineurin inhibitor (CNI) avoidance and late CNI withdrawal probably leads to higher acute rejection: late withdrawal compared with standard dose CNI (moderate certainty).
Calcineurin inhibitor (CNI) avoidance and late CNI withdrawal showed no clear difference in graft loss: avoidance compared with standard dose CNI (low certainty).
Calcineurin inhibitor (CNI) avoidance and late CNI withdrawal probably leads to lower graft loss: late withdrawal compared with standard dose CNI (moderate certainty).
It is very uncertain whether calcineurin inhibitors ± steroids changes death at final compared with placebo/no treatment/supportive treatment/steroids (very low certainty).
It is very uncertain whether calcineurin inhibitors ± steroids changes end‐stage kidney disease at final compared with placebo/no treatment/supportive treatment/steroids (very low certainty).
Calcineurin inhibitors ± steroids showed no clear difference in total remission at final compared with placebo/no treatment/supportive treatment/steroids (low certainty).
Calcineurin inhibitors ± steroids showed no clear difference in complete remission at final compared with placebo/no treatment/supportive treatment/steroids (low certainty).
It is very uncertain whether calcineurin inhibitors ± steroids changes recurrence of disease (relapse) at final compared with placebo/no treatment/supportive treatment/steroids (very low certainty).