Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

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No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 4 · 57.1%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%

COMPARISON 1. ARIPIPRAZOLE vs CLOZAPINE

Global state: No clinically important response (as defined by the original studies) · patients with schizophrenia

COMPARISON 1. ARIPIPRAZOLE showed no clear difference in global state: No clinically significant response compared with CLOZAPINE (low certainty).

1 finding from 1 review

Aripiprazole versus other atypical antipsychotics for schizophrenia 2014 · Cochrane Headline outcomes only
RR 1.05 [0.87, 1.27]
29 studies · 2132 participants
Low

COMPARISON 1. ARIPIPRAZOLE vs CLOZAPINE

Global state: Response ‐ proxy outcome ‐ mental state: 1. General ‐ average score (Brief Psychiatric Rating Scale by over 24 weeks · patients with schizophrenia

1 finding from 1 review

Aripiprazole versus other atypical antipsychotics for schizophrenia 2014 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 426 participants
Very low

COMPARISON 1. ARIPIPRAZOLE vs CLOZAPINE

Leaving the study early · patients with schizophrenia

It is very uncertain whether COMPARISON 1. ARIPIPRAZOLE changes leaving the study early ‐ Any reason compared with CLOZAPINE (very low certainty).

1 finding from 1 review

Aripiprazole versus other atypical antipsychotics for schizophrenia 2014 · Cochrane Headline outcomes only
RR 1.41 [0.46, 4.29]
3 studies · 240 participants
Very low

COMPARISON 1. ARIPIPRAZOLE vs CLOZAPINE

QoL · patients with schizophrenia

1 finding from 1 review

Aripiprazole versus other atypical antipsychotics for schizophrenia 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 132 participants
Very low

COMPARISON 1. ARIPIPRAZOLE vs CLOZAPINE

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

It is very uncertain whether COMPARISON 1. ARIPIPRAZOLE changes adverse effects: extrapyramidal effects compared with CLOZAPINE (very low certainty).

1 finding from 1 review

Aripiprazole versus other atypical antipsychotics for schizophrenia 2014 · Cochrane Headline outcomes only
RR 1.91 [0.75, 4.85]
8 studies · 520 participants
Very low

COMPARISON 1. ARIPIPRAZOLE vs CLOZAPINE

General functioning ‐ not measured · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Aripiprazole versus other atypical antipsychotics for schizophrenia 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

COMPARISON 1. ARIPIPRAZOLE vs CLOZAPINE

Service use ‐ not measured · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Aripiprazole versus other atypical antipsychotics for schizophrenia 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found