Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

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No studies found 2 · 28.6%GRADE not reported 1 · 14.3%Very low 4 · 57.1%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

CLOZAPINE + RISPERIDONE vs CLOZAPINE + SULPIRIDE (Kong 2001)

Clinical response: no clinically significant response in mental state: 20% to 50% reduction in PANSS total score · people with treatment‐resistant schizophrenia

It is very uncertain whether CLOZAPINE + RISPERIDONE changes clinical response: no clinically significant response in mental… compared with CLOZAPINE + SULPIRIDE (Kong 2001) (very low certainty).

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
RR 0.82 [0.4, 1.68]
1 study · 60 participants
Very low

CLOZAPINE + RISPERIDONE vs CLOZAPINE + SULPIRIDE (Kong 2001)

Weight gain · people with treatment‐resistant schizophrenia

It is very uncertain whether CLOZAPINE + RISPERIDONE changes adverse effects: weight gain compared with CLOZAPINE + SULPIRIDE (Kong 2001) (very low certainty).

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
RR 0.4 [0.08, 1.9]
1 study · 60 participants
Very low

CLOZAPINE + RISPERIDONE vs CLOZAPINE + SULPIRIDE (Kong 2001)

Clinical response: mean score/change in global state · people with treatment‐resistant schizophrenia

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
GRADE not reported

CLOZAPINE + RISPERIDONE vs CLOZAPINE + SULPIRIDE (Kong 2001)

Clinical response: mean score/change in mental state: mean PANSS total score (high = poor) · people with treatment‐resistant schizophrenia

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

CLOZAPINE + RISPERIDONE vs CLOZAPINE + SULPIRIDE (Kong 2001)

Leaving the study early · people with treatment‐resistant schizophrenia

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

CLOZAPINE + RISPERIDONE vs CLOZAPINE + SULPIRIDE (Kong 2001)

Service utilisation outcomes: hospital admission or days in hospital · people with treatment‐resistant schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CLOZAPINE + RISPERIDONE vs CLOZAPINE + SULPIRIDE (Kong 2001)

Quality of life/satisfaction with care for either recipients of care or carers: significant change in quality of life/satisfaction · people with treatment‐resistant schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found