Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 4 · 57.1%Very low 2 · 28.6%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%

CLOZAPINE + AMISULPIRIDE vs CLOZAPINE + QUETIAPINE (Genc 2007)

Clinical response: mean score/change in global state: mean CGI score (high = poor) Short term (8 weeks) · people with treatment‐resistant schizophrenia

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Very low

CLOZAPINE + AMISULPIRIDE vs CLOZAPINE + QUETIAPINE (Genc 2007)

Global state: Response ‐ proxy outcome ‐ mental state: 1. General ‐ average score (Brief Psychiatric Rating Scale by over 24 weeks · people with treatment‐resistant schizophrenia

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

CLOZAPINE + AMISULPIRIDE vs CLOZAPINE + QUETIAPINE (Genc 2007)

Leaving the study early · people with treatment‐resistant schizophrenia

It is very uncertain whether CLOZAPINE + AMISULPIRIDE changes leaving the study early: acceptability of treatment ‐ as measured by… compared with CLOZAPINE + QUETIAPINE (Genc 2007) (very low certainty).

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
RR 0.2 [0.02, 1.6]
1 study · 56 participants
Very low

CLOZAPINE + AMISULPIRIDE vs CLOZAPINE + QUETIAPINE (Genc 2007)

Service utilisation outcomes: hospital admission or days in hospital · people with treatment‐resistant schizophrenia

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
GRADE not reported

CLOZAPINE + AMISULPIRIDE vs CLOZAPINE + QUETIAPINE (Genc 2007)

Quality of life/satisfaction with care for either recipients of care or carers: significant change in quality of life/satisfaction · people with treatment‐resistant schizophrenia

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
GRADE not reported

CLOZAPINE + AMISULPIRIDE vs CLOZAPINE + QUETIAPINE (Genc 2007)

Clinical response: no clinically significant response in mental state · people with treatment‐resistant schizophrenia

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
GRADE not reported

CLOZAPINE + AMISULPIRIDE vs CLOZAPINE + QUETIAPINE (Genc 2007)

Weight gain · people with treatment‐resistant schizophrenia

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
GRADE not reported