Findings

What do systematic reviews say?

7 questions · 14 findings · 1 reviews · Schizophrenia

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No studies found 0 · 0%GRADE not reported 1 · 7.1%Very low 0 · 0%Low 0 · 0%Moderate 13 · 92.9%High 0 · 0%

CLOZAPINE vs Typical antipsychotics

Relapse · patients with schizophrenia

CLOZAPINE probably leads to lower relapse ‐ short term compared with TYPICAL ANTIPSYCHOTICS ‐ OVERALL (moderate certainty).

4 findings from 1 review

Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only
RR 0.62 [0.45, 0.84]
19 studies · 1303 participants
Moderate
Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only
RR 0.22 [0.14, 0.34]
4 studies · 578 participants
Moderate
Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only
RR 1.04 [0.61, 1.78]
4 studies · 396 participants
Moderate

Show 1 more finding

Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only
RR 0.17 [0.1, 0.3]
1 study · 423 participants
Moderate

CLOZAPINE vs Typical antipsychotics

Global state: no improvement ‐ medium termAs defined in each study · patients with schizophrenia

CLOZAPINE probably leads to lower global impression: 1. Not clinically improved ‐ short term compared with TYPICAL ANTIPSYCHOTICS (moderate certainty).

3 findings from 1 review

Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only
RR 0.71 [0.64, 0.79]
4 studies · 370 participants
Moderate
Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only
RR 0.83 [0.76, 0.91]
2 studies · 648 participants
Moderate
Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only
RR 0.72 [0.66, 0.79]
14 studies · 1119 participants
Moderate

CLOZAPINE vs Typical antipsychotics

Adverse effects 1. Blood problems · patients with schizophrenia

CLOZAPINE showed no clear difference in adverse effects 1. Blood problems compared with TYPICAL ANTIPSYCHOTICS; GRADE not reported.

1 finding from 1 review

Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only
RR 1.9 [0.97, 3.71]
5 studies · 827 participants
GRADE not reported

CLOZAPINE vs Typical antipsychotics

Adverse effects 4. Salivation ‐ too much · patients with schizophrenia

CLOZAPINE probably leads to higher adverse effects 4. Salivation ‐ too much compared with TYPICAL ANTIPSYCHOTICS (moderate certainty).

2 findings from 1 review

Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only
RR 2.01 [1.74, 2.32]
5 studies · 827 participants
Moderate
Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only
RR 2.25 [1.96, 2.58]
17 studies · 1479 participants
Moderate

CLOZAPINE vs Typical antipsychotics

Weight gain · patients with schizophrenia

CLOZAPINE probably leads to higher adverse effects 5. Weight gain compared with TYPICAL ANTIPSYCHOTICS (moderate certainty).

2 findings from 1 review

Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only
RR 1.33 [1.11, 1.59]
3 studies · 484 participants
Moderate
Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only
RR 1.28 [1.07, 1.53]
5 studies · 590 participants
Moderate

CLOZAPINE vs Typical antipsychotics

Unable to work · patients with schizophrenia

CLOZAPINE showed no clear difference in unable to work compared with TYPICAL ANTIPSYCHOTICS ‐ OVERALL (moderate certainty).

1 finding from 1 review

Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only
RR 0.87 [0.75, 1]
4 studies · 416 participants
Moderate

CLOZAPINE vs Typical antipsychotics

Adverse effects: 1. Blood problems ‐ decreased white cell count · patients with schizophrenia

CLOZAPINE probably leads to higher adverse effects: 1. Blood problems ‐ decreased white cell count compared with TYPICAL ANTIPSYCHOTICS ‐ OVERALL (moderate certainty).

1 finding from 1 review

Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only
RR 7.09 [1.96, 25.62]
13 studies · 1031 participants
Moderate