Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 66.7%Moderate 0 · 0%High 1 · 33.3%

Dropouts due to treatment · people who smoke

Bupropion leads to higher dropouts due to treatment compared with placebo/no pharmacological treatment (high certainty).

1 finding from 1 review

Antidepressants for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.44 [1.27, 1.65]
25 studies · 12346 participants
High

Dropouts due to treatment · people who smoke

Bupropion plus varenicline showed no clear difference in dropouts due to treatment compared with varenicline alone (low certainty).

1 finding from 1 review

Antidepressants for smoking cessation 2023 · Cochrane Headline outcomes only
RR 0.8 [0.45, 1.45]
4 studies · 1230 participants
Low

Dropouts due to treatment · people who smoke

Bupropion plus nicotine replacement therapy (NRT) showed no clear difference in dropouts due to treatment compared with NRT alone (low certainty).

1 finding from 1 review

Antidepressants for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.67 [0.95, 2.92]
3 studies · 737 participants
Low