It is very uncertain whether budesonide changes maintenance of histological response compared with placebo (very low certainty).
Budesonide showed no clear difference in adverse events compared with placebo (low certainty).
It is very uncertain whether budesonide changes withdrawals due to adverse events compared with placebo (very low certainty).
It is very uncertain whether budesonide changes serious adverse events compared with placebo (very low certainty).
Budesonide may leads to higher clinical response compared with mesalazine (low certainty).
Budesonide may leads to higher histological response compared with mesalazine (low certainty).
Budesonide showed no clear difference in adverse events compared with mesalazine (low certainty).
Budesonide showed no clear difference in withdrawals due to adverse events compared with mesalazine (low certainty).
Budesonide may leads to higher clinical response compared with mesalazine (low certainty).
Budesonide may leads to higher histological response compared with mesalazine (low certainty).
Budesonide showed no clear difference in adverse events compared with mesalazine (low certainty).
Budesonide may leads to lower incidence of acute mountain sickness (AMS)‐ Follow‐ up: From arrival… compared with placebo (low certainty).
The review found no eligible studies for this question.
The review found no eligible studies for this question.
Budesonide 3 mg showed no clear difference in induction of clinical remission (CDAI < 150) ‐ 8 weeks compared with placebo (low certainty).
Budesonide 9 mg probably leads to lower induction of clinical remission (CDAI < 150) ‐ 8 weeks compared with conventional steroids (moderate certainty).
Budesonide 9 mg showed no clear difference in withdrawal due to adverse events compared with conventional steroids (low certainty).
It is very uncertain whether budesonide 9 mg changes withdrawal due to disease worsening compared with conventional steroids (very low certainty).
Budesonide 9 mg probably leads to higher induction of clinical remission (CDAI < 150) ‐ 8 weeksThomsen 1998 compared with mesalamine (moderate certainty).