Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

8 questions · 10 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 30%Moderate 3 · 30%High 4 · 40%

Bortezomib vs no bortezomib

Diarrhoea · All patients with a diagnosis of multiple myeloma

Bortezomib probably leads to higher adverse Events: Diarrhoea ‐ Bortezomib versus no bortezomib (same… compared with no bortezomib (moderate certainty).

2 findings from 1 review

Bortezomib vs no bortezomib

Thrombocytopenia · All patients with a diagnosis of multiple myeloma

Bortezomib leads to higher adverse Events: Thrombocytopenia ‐ Bortezomib versus no bortezomib… compared with no bortezomib (high certainty).

2 findings from 1 review

Bortezomib vs no bortezomib

Adverse Events: Infections (All) ‐ Bortezomib versus no bortezomib (same background therapy) · All patients with a diagnosis of multiple myeloma

Bortezomib showed no clear difference in adverse Events: Infections (All) ‐ Bortezomib versus no bortezomib… compared with no bortezomib (high certainty).

1 finding from 1 review

Bortezomib vs no bortezomib

Adverse effects (cardiac) · All patients with a diagnosis of multiple myeloma

Bortezomib showed no clear difference in adverse Events: Cardiac Disorders ‐ Bortezomib versus no bortezomib… compared with no bortezomib (moderate certainty).

1 finding from 1 review

Bortezomib vs no bortezomib

Adverse Events: Peripheral Neuropathy ‐ Bortezomib versus no bortezomib (same background therapy) · All patients with a diagnosis of multiple myeloma

Bortezomib may leads to higher adverse Events: Peripheral Neuropathy ‐ Bortezomib versus no… compared with no bortezomib (low certainty).

1 finding from 1 review

Bortezomib vs no bortezomib

Adverse Events: Infections (All) ‐ Bortezomib versus no bortezomib (different background therapy or other agents) · All patients with a diagnosis of multiple myeloma

Bortezomib may leads to higher adverse Events: Infections (All) ‐ Bortezomib versus no bortezomib… compared with no bortezomib (low certainty).

1 finding from 1 review

Bortezomib vs no bortezomib

Adverse Events: Cardiac Disorders ‐ Bortezomib versus no bortezomib (different background therapy or other agents) · All patients with a diagnosis of multiple myeloma

Bortezomib leads to higher adverse Events: Cardiac Disorders ‐ Bortezomib versus no bortezomib… compared with no bortezomib (high certainty).

1 finding from 1 review

Bortezomib vs no bortezomib

Adverse Events: Peripheral Neuropathy ‐ Bortezomib versus no bortezomib (different background therapy or other agents) · All patients with a diagnosis of multiple myeloma

Bortezomib leads to higher adverse Events: Peripheral Neuropathy ‐ Bortezomib versus no… compared with no bortezomib (high certainty).

1 finding from 1 review