Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Gut

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 28.6%Low 3 · 42.9%Moderate 2 · 28.6%High 0 · 0%

Clinical improvement (dichotomous) · active EoE patients

Biologics showed no clear difference in clinical improvement (dichotomous) compared with placebo (low certainty).

1 finding from 1 review

Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
RR 1.14 [0.85, 1.52]
5 studies · 410 participants
Low

Clinical improvement (continuous) · active EoE patients

1 finding from 1 review

Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 387 participants
Moderate

Histological improvement (dichotomous) · active EoE patients

Biologics probably leads to higher histological improvement (dichotomous) compared with placebo (moderate certainty).

1 finding from 1 review

Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
RR 6.73 [2.58, 17.52]
8 studies · 925 participants
Moderate

Histological improvement (continuous) · active EoE patients

1 finding from 1 review

Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 370 participants
Very low

Endoscopic improvement (dichotomous) · active EoE patients

1 finding from 1 review

Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 11 participants
Low

Endoscopic improvement (continuous) · active EoE patients

1 finding from 1 review

Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 197 participants
Very low

Withdrawals due to adverse events · active EoE patients

Biologics showed no clear difference in withdrawals due to adverse events 12 to 44 weeks compared with placebo (low certainty).

1 finding from 1 review

Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
RR 1.55 [0.88, 2.74]
8 studies · 792 participants
Low