Findings

What do systematic reviews say?

8 questions · 8 findings · 4 reviews · Endodontics and dental trauma

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No studies found 0 · 0%GRADE not reported 8 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Biodentine vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure

Biodentine may increase pulpotomy success versus calcium hydroxide at marginal significance (ungraded).

1 finding from 1 review

Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months
OR 6.03 [0.97, 37.6]
2 studies
GRADE not reported

Biodentine vs Mineral trioxide aggregate (MTA)

Tooth discoloration · Patients with carious pulp exposure in permanent teeth undergoing DPC or pulpotomy

More tooth discoloration was observed with MTA than with Biodentine, but odds ratios were implausibly large and not pooled (3 RCTs; ungraded).

1 finding from 1 review

Comparative efficacy of materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth: A… 2023 All outcomes
≥6 months follow-up · Dental/endodontic clinical settings across multiple countries (university, hospital, specialist and general dental practice); permanent teeth with carious pulp exposure
Tooth discoloration was recorded in 4 trials; the 3 Biodentine-vs-MTA trials consistently showed more discoloration with MTA (Awawdeh 2018: 27/35 MTA vs 0/34 BD; Parinyaprom 2018: 11/31 MTA vs 0/29 BD; Uesrichai 2019:…
3 studies
GRADE not reported

Biodentine vs Mineral trioxide aggregate (MTA)

Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing DPC or pulpotomy

MTA and Biodentine performed comparably for clinical and radiographic success (5 RCTs, not pooled; ungraded).

1 finding from 1 review

Comparative efficacy of materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth: A… 2023 All outcomes
≥6 months follow-up · Dental/endodontic clinical settings across multiple countries (university, hospital, specialist and general dental practice); permanent teeth with carious pulp exposure
Biodentine vs MTA was the second most frequent comparison (5 RCTs) for the primary outcome but was not pooled owing to substantial clinical/statistical heterogeneity; the panel of per-trial forest plots (Figure 8)…
5 studies
GRADE not reported

Partial pulpotomy with tri-calcium silicate material (MTA or Biodentine) vs No comparator

Overall success (composite of clinical and radiographic success) · Adults aged 18 years or older with mature permanent teeth and carious pulp exposure

Partial pulpotomy with MTA or Biodentine had a pooled success rate of 86.8%.

1 finding from 1 review

Partial pulpotomy for carious pulp exposure in adult mature permanent teeth: a systematic review and meta-analysis. 2025 All outcomes
At least 1 year · MTA or Biodentine
Success rate (%) 86.8 [83.78, 89.82]
Studies not reported
GRADE not reported

Partial pulpotomy with tri-calcium silicate material (MTA or Biodentine) vs Partial pulpotomy with calcium hydroxide

Overall success (composite of clinical and radiographic success) · Adults aged 18 years or older with mature permanent teeth and carious pulp exposure

Partial pulpotomy with tri-calcium silicate cements (MTA/Biodentine) has a much higher success rate than with calcium hydroxide in adults (86.8% vs 34.3%; ungraded).

1 finding from 1 review

Partial pulpotomy for carious pulp exposure in adult mature permanent teeth: a systematic review and meta-analysis. 2025 All outcomes
>=1 year (subgroups at 1, 2, 5 years) · Dental/endodontic clinical practice · Capping material (tri-calcium silicate vs calcium hydroxide)
MD 52.5
Studies not reported
GRADE not reported

Pulpotomy with Biodentine vs Pulpotomy with Calcium Enriched Mixture (CEM)

Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure

Biodentine had a significantly higher pulpotomy success rate than CEM (indirect comparison; numeric estimate not available); ungraded.

1 finding from 1 review

Outcome of pulpotomy in permanent teeth with irreversible pulpitis: a systematic review and meta-analysis. 2022 All outcomes
>=6 months · Clinical (endodontic/dental) · Pulp capping material: Biodentine vs CEM
Biodentine demonstrated a statistically significantly higher success rate than CEM (indirect comparison; Supplementary Table S5, not available).
Studies not reported
GRADE not reported

Pulpotomy with Biodentine vs Pulpotomy with calcium hydroxide (Ca(OH)2)

Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure

Biodentine had a significantly higher pulpotomy success rate than calcium hydroxide (indirect comparison; numeric estimate not available); ungraded.

1 finding from 1 review

Outcome of pulpotomy in permanent teeth with irreversible pulpitis: a systematic review and meta-analysis. 2022 All outcomes
>=6 months · Clinical (endodontic/dental) · Pulp capping material: Biodentine vs calcium hydroxide
Biodentine demonstrated a statistically significantly higher success rate than calcium hydroxide (indirect comparison; Supplementary Table S5, not available).
Studies not reported
GRADE not reported

Pulpotomy with Biodentine vs Pulpotomy with mineral trioxide aggregate (MTA)

Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure

Biodentine had a significantly higher pulpotomy success rate than MTA (indirect comparison; numeric estimate not available); ungraded.

1 finding from 1 review

Outcome of pulpotomy in permanent teeth with irreversible pulpitis: a systematic review and meta-analysis. 2022 All outcomes
>=6 months · Clinical (endodontic/dental) · Pulp capping material: Biodentine vs MTA
Biodentine demonstrated a statistically significantly higher success rate than MTA (indirect comparison; numeric estimate in Supplementary Table S5, not available).
Studies not reported
GRADE not reported