Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

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No studies found 3 · 42.9%GRADE not reported 0 · 0%Very low 3 · 42.9%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) vs beta‐lactam (ceftriaxone)

All‐cause mortality during hospital stay and all‐cause mortality at 1 year · people with infective endocarditis due to penicillin‐susceptible Streptococci

The review found no eligible studies for this question.

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) vs beta‐lactam (ceftriaxone)

Cure · people with infective endocarditis due to penicillin‐susceptible Streptococci

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) showed no clear difference in cure compared with beta‐lactam (ceftriaxone) (low certainty).

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
RR 0.69 [0.44, 1.1]
1 study · 67 participants
Low

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) vs beta‐lactam (ceftriaxone)

Adverse events · people with infective endocarditis due to penicillin‐susceptible Streptococci

It is very uncertain whether beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) changes adverse events compared with beta‐lactam (ceftriaxone) (very low certainty).

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
RR 0.58 [0.15, 2.24]
1 study · 67 participants
Very low

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) vs beta‐lactam (ceftriaxone)

Congestive heart failure · people with infective endocarditis due to penicillin‐susceptible Streptococci

The review found no eligible studies for this question.

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) vs beta‐lactam (ceftriaxone)

Septic embolism · people with infective endocarditis due to penicillin‐susceptible Streptococci

The review found no eligible studies for this question.

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) vs beta‐lactam (ceftriaxone)

Need for cardiac surgical interventions · people with infective endocarditis due to penicillin‐susceptible Streptococci

It is very uncertain whether beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) changes need for cardiac surgical interventions compared with beta‐lactam (ceftriaxone) (very low certainty).

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
RR 1.75 [0.65, 4.67]
1 study · 67 participants
Very low

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) vs beta‐lactam (ceftriaxone)

Uncontrolled infection · people with infective endocarditis due to penicillin‐susceptible Streptococci

It is very uncertain whether beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) changes uncontrolled infection compared with beta‐lactam (ceftriaxone) (very low certainty).

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
RR 0.97 [0.06, 14.88]
1 study · 67 participants
Very low