Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews · Schizophrenia

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 100%Moderate 0 · 0%High 0 · 0%

Benzodiazepines vs ANTIHISTAMINES + ANTIPSYCHOTICS

Adverse effects: 1. Sedation · psychosis‐induced aggression or agitation

Benzodiazepines may leads to lower tranquillisation or asleep: sedation ‐ medium term ‐ lorazepam vs… compared with antihistamines plus antipsychotics (low certainty).

1 finding from 1 review

Benzodiazepines for psychosis‐induced aggression or agitation 2017 · Cochrane Headline outcomes only
RR 0.91 [0.84, 0.98]
1 study · 200 participants
Low

BENZODIAZEPINES + ANTIPSYCHOTICS vs same enzodiazepines

Global state: no improvement ‐ medium termAs defined in each study · psychosis‐induced aggression or agitation

Benzodiazepines + antipsychotics showed no clear difference in global state: no improvement ‐ lorazepam + risperidone vs lorazepam… compared with same enzodiazepines (low certainty).

1 finding from 1 review

Benzodiazepines for psychosis‐induced aggression or agitation 2017 · Cochrane Headline outcomes only
RR 0.86 [0.45, 1.64]
1 study · 20 participants
Low