Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 25%Low 1 · 25%Moderate 2 · 50%High 0 · 0%

Clinical remission · Patients with active Crohn's disease

Azathioprine or 6‐mercaptopurine showed no clear difference in clinical remission compared with placebo (moderate certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for induction of remission in Crohn's disease 2016 · Cochrane Headline outcomes only
RR 1.23 [0.97, 1.55]
5 studies · 380 participants
Moderate

Clinical remission · Patients with active Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes clinical remission compared with 5‐ASA or Sulfasalzine (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for induction of remission in Crohn's disease 2016 · Cochrane Headline outcomes only
RR 1.24 [0.8, 1.91]
2 studies · 156 participants
Very low

Clinical remission1 · Patients with active Crohn's disease

Azathioprine or 6‐mercaptopurine showed no clear difference in clinical remission1 compared with methotrexate (low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for induction of remission in Crohn's disease 2016 · Cochrane Headline outcomes only
RR 1.13 [0.85, 1.49]
3 studies · 143 participants
Low

Clinical remission or improvement · Patients with active Crohn's disease

Azathioprine or 6‐mercaptopurine showed no clear difference in clinical remission or improvement compared with placebo (moderate certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for induction of remission in Crohn's disease 2016 · Cochrane Headline outcomes only
RR 1.26 [0.98, 1.62]
8 studies · 434 participants
Moderate