What do systematic reviews say?

Dopamine agonist vs placebo

Any dopamine agonist showed no clear difference in dropouts compared with placebo (moderate certainty).

• Dopamine agonists for the treatment of cocaine dependence 2015 · Cochrane Headline outcomes only
  RR 1.04 [0.94, 1.14]
  20 studies · 1656 participants
  Moderate

Dopamine agonist vs placebo

Any dopamine agonist showed no clear difference in adverse events as N of participants with at least one adverse event compared with placebo (moderate certainty).

• Dopamine agonists for the treatment of cocaine dependence 2015 · Cochrane Headline outcomes only
  RR 1.27 [0.66, 2.44]
  7 studies · 252 participants
  Moderate

Dopamine agonist vs placebo

Any dopamine agonist showed no clear difference in abstinence (objective) Participants abstinent at the end of… compared with placebo (low certainty).

• Dopamine agonists for the treatment of cocaine dependence 2015 · Cochrane Headline outcomes only
  RR 1.12 [0.85, 1.47]
  11 studies · 731 participants
  Low

Dopamine agonist vs placebo

Any dopamine agonist showed no clear difference in abstinence at compared with placebo (low certainty).

• Dopamine agonists for the treatment of cocaine dependence 2015 · Cochrane Headline outcomes only
  RR 1.1 [0.61, 1.98]
  4 studies · 136 participants
  Low

Dopamine agonist vs placebo

• Dopamine agonists for the treatment of cocaine dependence 2015 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 202 participants
  Low