Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Musculoskeletal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 57.1%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%

Any cold therapy vs no cold therapy following total knee replacement

Blood lossTime point: mean 48 hours, range 1 to 13 days. Higher blood loss indicates a worse outcome. · people undergoing total knee replacement

1 finding from 1 review

Cryotherapy following total knee replacement 2023 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 956 participants
Low

Any cold therapy vs no cold therapy following total knee replacement

Pain at post‐operative day 2Scale from 0 (best) to 10 (worst). · people undergoing total knee replacement

1 finding from 1 review

Cryotherapy following total knee replacement 2023 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 530 participants
Low

Any cold therapy vs no cold therapy following total knee replacement

Transfusion rate · people undergoing total knee replacement

It is very uncertain whether any cold therapy changes transfusion rate compared with no cold therapy following total knee replacement (very low certainty).

1 finding from 1 review

Cryotherapy following total knee replacement 2023 · Cochrane Headline outcomes only
RR 2.13 [0.04, 109.63]
2 studies · 91 participants
Very low

Any cold therapy vs no cold therapy following total knee replacement

Range of motion at discharge Scale from: 0 to 125. · people undergoing total knee replacement

1 finding from 1 review

Cryotherapy following total knee replacement 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 174 participants
Low

Any cold therapy vs no cold therapy following total knee replacement

Function Standardised scale with positive score indicating a better outcome. Scale from 0 (worst) to 100 (best). · people undergoing total knee replacement

1 finding from 1 review

Cryotherapy following total knee replacement 2023 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 296 participants
Very low

Any cold therapy vs no cold therapy following total knee replacement

Adverse events Adverse events included discomfort, local skin reactions, superficial infections, cold induced injuries and thrombolytic events · people undergoing total knee replacement

It is very uncertain whether any cold therapy changes total adverse eventsAdverse events included discomfort, local skin… compared with no cold therapy following total knee replacement (very low certainty).

1 finding from 1 review

Cryotherapy following total knee replacement 2023 · Cochrane Headline outcomes only
RR 1.3 [0.53, 3.2]
16 studies · 1199 participants
Very low

Any cold therapy vs no cold therapy following total knee replacement

Withdrawals due to adverse events · people undergoing total knee replacement

It is very uncertain whether any cold therapy changes withdrawals due to adverse events compared with no cold therapy following total knee replacement (very low certainty).

1 finding from 1 review

Cryotherapy following total knee replacement 2023 · Cochrane Headline outcomes only
RR 2.71 [0.42, 17.38]
19 studies · 1347 participants
Very low