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What do systematic reviews say?

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Evidence found and GRADE certainty

14 questions · 20 findings · 1 reviews · Schizophrenia

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No studies found 0 · 0%GRADE not reported 6 · 30%Very low 3 · 15%Low 9 · 45%Moderate 2 · 10%High 0 · 0%

Any antiglucocorticoid vs placebo

Quality of life: improved to an important degree · people with psychosis
3 findings from 1 review

Any antiglucocorticoid vs placebo

Global state: general ‐no clinically significant improvement ‐ data only for mifepristone < 30% improvement on BPRS · people with psychosis

It is very uncertain whether any antiglucocorticoid changes global state: general ‐no clinically significant improvement ‐ data… compared with placebo (very low certainty).

1 finding from 1 review

Any antiglucocorticoid vs placebo

Adverse effects: 1. General ‐ overall number of events · people with psychosis

Any antiglucocorticoid probably leads to higher adverse effects: 1. General ‐ overall number of events compared with placebo (moderate certainty).

2 findings from 1 review

Any antiglucocorticoid vs placebo

Global state: 1. General ‐ no clinically significant improvement ‐ short term < 30% improvement on BPRS · people with psychosis

Any antiglucocorticoid may leads to lower global state: 1. General ‐ no clinically significant improvement ‐… compared with placebo (low certainty).

1 finding from 1 review

Any antiglucocorticoid vs placebo

Global state: 2. Specific: positive ‐ no clinically significant improvement ‐ short term (< 50% improvement on BPRS PSS) · people with psychosis

Any antiglucocorticoid may leads to lower global state: 2. Specific: positive ‐ no clinically significant… compared with placebo (low certainty).

1 finding from 1 review