Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 20%Moderate 3 · 60%High 1 · 20%

Antihistamine‐decongestant vs placebo

Adverse effects: all · otherwise healthy adults and children with common cold symptoms

Antihistamine‐decongestant showed no clear difference in adverse effects: all compared with placebo (moderate certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 1.58 [0.78, 3.21]
7 studies · 842 participants
Moderate

Antihistamine‐decongestant vs placebo

Adverse effects: insomnia · otherwise healthy adults and children with common cold symptoms

Antihistamine‐decongestant showed no clear difference in adverse effects: insomnia compared with placebo (moderate certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 2.89 [0.88, 9.56]
2 studies · 344 participants
Moderate

Antihistamine‐decongestant vs placebo

Adverse effects: dry mouth · otherwise healthy adults and children with common cold symptoms

Antihistamine‐decongestant leads to higher adverse effects: dry mouth compared with placebo (high certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 3.75 [1.74, 8.1]
4 studies · 640 participants
High

Antihistamine‐decongestant vs placebo

Adverse effects: gastrointestinal upset · otherwise healthy adults and children with common cold symptoms

Antihistamine‐decongestant showed no clear difference in adverse effects: gastrointestinal upset compared with placebo (moderate certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 2.81 [0.64, 12.33]
2 studies · 296 participants
Moderate

Antihistamine‐decongestant vs placebo

Adverse effects: drowsiness, hypersomnia, and excessive sleepiness · otherwise healthy adults and children with common cold symptoms

Antihistamine‐decongestant showed no clear difference in adverse effects: drowsiness, hypersomnia, and excessive sleepiness compared with placebo (low certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 1.38 [0.63, 3]
5 studies · 692 participants
Low