Findings

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4 questions · 5 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 80%Moderate 1 · 20%High 0 · 0%

Antihistamine‐analgesic vs placebo

Global evaluation · otherwise healthy adults and children with common cold symptoms

Antihistamine‐analgesic probably leads to lower global evaluation compared with placebo (moderate certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 0.33 [0.23, 0.46]
1 study · 582 participants
Moderate

Antihistamine‐analgesic vs placebo

Adverse effects: drowsiness, hypersomnia, and excessive sleepiness · otherwise healthy adults and children with common cold symptoms

Antihistamine‐analgesic showed no clear difference in adverse effects: drowsiness, hypersomnia, and excessive sleepiness compared with placebo (low certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 1.64 [0.48, 5.59]
2 studies · 272 participants
Low

Antihistamine‐analgesic‐decongestant vs placebo

Global evaluation · otherwise healthy adults and children with common cold symptoms

Antihistamine‐analgesic‐decongestant showed no clear difference in global evaluation: after 3 days of treatment (included children 2 to… compared with placebo (low certainty).

2 findings from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 0.34 [0.09, 1.31]
1 study · 109 participants
Low
Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 0.47 [0.33, 0.67]
2 studies · 548 participants
Low

Antihistamine‐analgesic‐decongestant vs placebo

Global evaluation: after 5 days of treatment (included children 2 to 12 years old only) · otherwise healthy adults and children with common cold symptoms

Antihistamine‐analgesic‐decongestant showed no clear difference in global evaluation: after 5 days of treatment (included children 2 to… compared with placebo (low certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 1.17 [0.49, 2.77]
1 study · 83 participants
Low