Findings

What do systematic reviews say?

10 questions · 10 findings · 2 reviews · Developmental, Psychosocial and Learning Problems

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No studies found 2 · 20%GRADE not reported 0 · 0%Very low 5 · 50%Low 3 · 30%Moderate 0 · 0%High 0 · 0%

Antidepressants vs placebo

Irritability · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

1 finding from 1 review

Pharmacological intervention for irritability, aggression, and self‐injury in autism spectrum disorder (ASD) 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 267 participants
Low

Antidepressants vs placebo

Aggression · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological intervention for irritability, aggression, and self‐injury in autism spectrum disorder (ASD) 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs placebo

Adverse effects · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

Antidepressants may leads to higher adverse effects compared with placebo (low certainty).

1 finding from 1 review

Pharmacological intervention for irritability, aggression, and self‐injury in autism spectrum disorder (ASD) 2023 · Cochrane Headline outcomes only
RR 4.16
10 studies · 815 participants
Low

Antidepressants vs placebo

Suicide‐related outcomes Timing of outcome assessment: end of treatment (6 to 12 weeks treatment duration) · patients with borderline personality disorder

1 finding from 1 review

Pharmacological interventions for people with borderline personality disorder 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 45 participants
Very low

Antidepressants vs placebo

Psychosocial functioning Measured by: clinicians and self‐rated Timing of outcome assessment: end of treatment · patients with borderline personality disorder

1 finding from 1 review

Pharmacological interventions for people with borderline personality disorder 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 161 participants
Very low

Antidepressants vs placebo

Interpersonal problems Timing of outcome assessment: end of treatment (32 days to 24 weeks) · patients with borderline personality disorder

1 finding from 1 review

Pharmacological interventions for people with borderline personality disorder 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 119 participants
Very low

Antidepressants vs placebo

Attrition Timing of outcome assessment: end of treatment · patients with borderline personality disorder

Antidepressants may leads to higher attrition Timing of outcome assessment: end of treatment (5 weeks to… compared with placebo (low certainty).

1 finding from 1 review

Pharmacological interventions for people with borderline personality disorder 2022 · Cochrane Headline outcomes only
RR 1.07
6 studies · 289 participants
Low

Antidepressants vs placebo

Non‐serious adverse events Timing of outcome assessment: end of treatment · patients with borderline personality disorder

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for people with borderline personality disorder 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs placebo

BPD symptom severity Measured by: clinicians and self‐rated Timing of outcome assessment: end of treatment · patients with borderline personality disorder

1 finding from 1 review

Pharmacological interventions for people with borderline personality disorder 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 87 participants
Very low

Antidepressants vs placebo

Deliberate self‐harm · patients with borderline personality disorder

1 finding from 1 review

Pharmacological interventions for people with borderline personality disorder 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low