Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

11 questions · 11 findings · 1 reviews · Drugs and Alcohol

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 6 · 54.5%Moderate 4 · 36.4%High 1 · 9.1%

Antidepressants vs placebo

Adverse events ‐ Withdrawn for medical reasons · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants probably leads to higher adverse events ‐ Withdrawn for medical reasons compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants vs placebo according to any definition

Dropout ‐ Studies with low risk of bias · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants showed no clear difference in dropout ‐ Studies with low risk of bias compared with placebo according to any definition (high certainty).

1 finding from 1 review

Antidepressants vs placebo according to any definition

> 50% reduction in depressive symptoms · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants showed no clear difference in severity of depression dichotomous measures ‐ >50% reduction in… compared with placebo according to any definition (low certainty).

1 finding from 1 review

Antidepressants vs placebo according to any definition

Severity of depression dichotomous measures ‐ "very much" or "much" improved on the Clinical Global Impression Scale · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants may leads to higher severity of depression dichotomous measures ‐ "very much" or "much"… compared with placebo according to any definition (low certainty).

1 finding from 1 review

Antidepressants vs placebo according to any definition

Adverse events ‐ Withdrawn for medical reasons · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants probably leads to higher adverse events ‐ Withdrawn for medical reasons compared with placebo according to any definition (moderate certainty).

1 finding from 1 review

Antidepressants vs placebo

Severity of depression dichotomous measures ‐ "very much" or "much" improved on the Clinical Global Impression Scale · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants may leads to higher severity of depression dichotomous measures ‐ "very much" or "much"… compared with placebo (low certainty).

1 finding from 1 review

Antidepressants vs placebo

> 50% reduction in depressive symptoms · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants showed no clear difference in severity of depression dichotomous measures ‐ >50% reduction in… compared with placebo (low certainty).

1 finding from 1 review