Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

31 questions · 31 findings · 3 reviews · Headline outcomes only

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 8 · 25.8%Low 20 · 64.5%Moderate 3 · 9.7%High 0 · 0%

Monoclonal antibody vs polyclonal antibody

Post‐transplantation lymphoproliferative disorder Number of participants diagnosed with PTLD · heart transplant recipients

Monoclonal antibody showed no clear difference in post‐transplantation lymphoproliferative disorder Number of… compared with polyclonal antibody (low certainty).

1 finding from 1 review

Summary of findings: monoclonal antibody KB001‐A vs placebo

Respiratory function number of episodes of a drop in FEV1 (unit of measurement not given) · children (12 or over) and adults with cystic fibrosis and lung infection

It is very uncertain whether summary of findings: monoclonal antibody KB001‐A changes respiratory function number of episodes of a drop in FEV1 (unit of… compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings: monoclonal antibody KB001‐A vs placebo

Number experiencing adverse effects · children (12 or over) and adults with cystic fibrosis and lung infection

It is very uncertain whether summary of findings: monoclonal antibody KB001‐A changes adverse events number of participants experiencing adverse events compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings: monoclonal antibody KB001‐A vs placebo

Need for antibiotics time to need for antibiotics · children (12 or over) and adults with cystic fibrosis and lung infection

Summary of findings: monoclonal antibody KB001‐A showed no clear difference in need for antibiotics time to need for antibiotics compared with placebo (moderate certainty).

1 finding from 1 review

Antibody vs other antibody (stratified by antibody type)

Failure of acute rejection reversal · kidney transplant recipients: steroid‐resistant rejection episodes

Antibody showed no clear difference in failure of acute rejection reversal compared with other antibody (stratified by antibody type) (low certainty).

1 finding from 1 review

Antibody vs other antibody (stratified by antibody type)

Recurrent rejection · kidney transplant recipients: steroid‐resistant rejection episodes

Antibody showed no clear difference in recurrent rejection compared with other antibody (stratified by antibody type) (low certainty).

1 finding from 1 review

Antibody vs other antibody (stratified by antibody type)

Graft loss censored for death · kidney transplant recipients: steroid‐resistant rejection episodes

Antibody showed no clear difference in graft loss censored for death compared with other antibody (stratified by antibody type) (low certainty).

1 finding from 1 review

Antibody vs other antibody (stratified by antibody type)

Graft loss or death with a functioning graft · kidney transplant recipients: steroid‐resistant rejection episodes

Antibody showed no clear difference in graft loss or death with a functioning graft compared with other antibody (stratified by antibody type) (low certainty).

1 finding from 1 review

Antibody vs other antibody (stratified by antibody type)

Adverse effects ‐ Bacterial infection clinical assessment · kidney transplant recipients: steroid‐resistant rejection episodes

It is very uncertain whether antibody changes treatment adverse events: bacterial infection compared with other antibody (stratified by antibody type) (very low certainty).

1 finding from 1 review