Antibiotics leads to lower pain ‐ pain at 2 to 3 days compared with placebo (high certainty).
Antibiotics showed no clear difference in pain ‐ pain at 4 to 7 days compared with placebo (high certainty).
Antibiotics probably leads to lower pain ‐ pain at 10 to 12 days compared with placebo (moderate certainty).
Antibiotics probably leads to lower sore throat: day 3 compared with control (moderate certainty).
Antibiotics showed no clear difference in fever: day 3 compared with control (high certainty).
Antibiotics leads to lower headache: day 3 compared with control (high certainty).
Antibiotics leads to lower otitis media (within 14 days, clinical diagnosis) compared with control (high certainty).
Immediate antibiotics showed no clear difference in pain ‐ Pain at 11 to 14 days compared with expectant observation (low certainty).
Immediate antibiotics may leads to lower pain ‐ Pain at 2 to 3 days compared with expectant observation (low certainty).
Immediate antibiotics showed no clear difference in pain ‐ Pain at 3 to 7 days compared with expectant observation (moderate certainty).