Antibiotics probably leads to lower sore throat: day 3 compared with control (moderate certainty).
Antibiotics showed no clear difference in fever: day 3 compared with control (high certainty).
Antibiotics leads to lower headache: day 3 compared with control (high certainty).
Antibiotics leads to lower pain ‐ pain at 2 to 3 days compared with placebo (high certainty).
Antibiotics showed no clear difference in pain ‐ pain at 4 to 7 days compared with placebo (high certainty).
Antibiotics probably leads to lower pain ‐ pain at 10 to 12 days compared with placebo (moderate certainty).
Antibiotics leads to lower otitis media (within 14 days, clinical diagnosis) compared with control (high certainty).
Immediate antibiotics showed no clear difference in pain ‐ Pain at 11 to 14 days compared with expectant observation (low certainty).
Immediate antibiotics may leads to lower pain ‐ Pain at 2 to 3 days compared with expectant observation (low certainty).
Immediate antibiotics showed no clear difference in pain ‐ Pain at 3 to 7 days compared with expectant observation (moderate certainty).