Resolution of purulent secretion · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging
Antibiotics leads to higher severity or duration of different clinical symptoms: resolution of… compared with placebo (high certainty).
1 finding from 1 review
Side effects – overall · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging
Antibiotics leads to higher side effects: total compared with placebo (high certainty).
1 finding from 1 review
Interventions side effects: diarrhoea · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging
Antibiotics leads to higher side effects: diarrhoea compared with placebo (high certainty).
1 finding from 1 review
Clinical failure · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging
Antibiotics leads to lower clinical failure compared with placebo (high certainty).
1 finding from 1 review
Exacerbations · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…
Antibiotics probably leads to lower number of people with one or more exacerbations WMD of compared with placebo (moderate certainty).
1 finding from 1 review
Annual Exacerbation Rates · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…
Antibiotics probably leads to lower rate of exacerbation per patient/year WMD of compared with placebo (moderate certainty).
1 finding from 1 review
HRQoL: total score · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…
1 finding from 1 review
All‐cause mortality WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…
Antibiotics showed no clear difference in all‐cause mortality WMD of compared with placebo (moderate certainty).
1 finding from 1 review
Serious adverse events WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…
Antibiotics showed no clear difference in serious adverse events WMD of compared with placebo (moderate certainty).
1 finding from 1 review
Any adverse event WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…
Antibiotics showed no clear difference in any adverse event WMD of compared with placebo (moderate certainty).
1 finding from 1 review
FEV1 · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…
1 finding from 1 review
Treatment failure within 4 weeks ‐ current drugs only · exacerbations of COPD
Antibiotics may leads to lower treatment failure within 4 weeks ‐ current drugs only compared with placebo (low certainty).
1 finding from 1 review
Adverse events (timing not specified) · exacerbations of COPD
Antibiotics showed no clear difference in adverse events ‐ overall (any adverse events not specified) compared with placebo overall (moderate certainty).
1 finding from 1 review
All‐cause mortality · exacerbations of COPD
Antibiotics showed no clear difference in all‐cause mortality compared with placebo (low certainty).
1 finding from 1 review
Treatment failure within 4 weeks ‐ current drugs only ‐ inpatient · exacerbations of COPD
Antibiotics showed no clear difference in treatment failure within 4 weeks ‐ current drugs only ‐ inpatient compared with placebo (moderate certainty).
1 finding from 1 review
Treatment failure within 4 weeks ‐ drugs not currently used ‐ ICU · exacerbations of COPD
Antibiotics probably leads to lower treatment failure within 4 weeks ‐ drugs not currently used ‐ ICU compared with placebo (moderate certainty).
1 finding from 1 review
Length of stay (inpatients only) · exacerbations of COPD
1 finding from 1 review
Duration of hospital stay (days) ‐ ICU patients · exacerbations of COPD
1 finding from 1 review
Inpatient mortality · exacerbations of COPD
Antibiotics showed no clear difference in all‐cause mortality ‐ inpatients compared with placebo (moderate certainty).
1 finding from 1 review
ICU mortality · exacerbations of COPD
Antibiotics probably leads to lower all‐cause mortality ‐ ICU patients compared with placebo (moderate certainty).
1 finding from 1 review