Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 66.7%Low 0 · 0%Moderate 1 · 33.3%High 0 · 0%

Antibiotics vs placebo

All‐cause mortality WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in all‐cause mortality WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) 2018 · Cochrane Headline outcomes only
OR 0.87 [0.66, 1.15]
6 studies · 3309 participants
Moderate

Single‐dose antibiotic vs 24 hours of antibiotics

All‐cause mortality · people undergoing laparotomy for penetrating abdominal trauma

1 finding from 1 review

Prophylactic antibiotics for penetrating abdominal trauma: duration of use and antibiotic choice 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 360 participants
Very low

More than 24 hours of antibiotics vs 24 hours of antibiotics

All‐cause mortality · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether more than 24 hours of antibiotics changes mortality compared with 24 hours of antibiotics (very low certainty).

1 finding from 1 review

Prophylactic antibiotics for penetrating abdominal trauma: duration of use and antibiotic choice 2019 · Cochrane Headline outcomes only
OR 1.67 [0.73, 3.82]
7 studies · 1261 participants
Very low