Findings

What do systematic reviews say?

5 questions · 6 findings · 1 reviews · Kidney and Transplant

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 50%Moderate 3 · 50%High 0 · 0%

Antibiotic prophylaxis vs placebo, no treatment or surveillance only

Number of participants with symptomatic UTI · primary VUR

Antibiotic prophylaxis showed no clear difference in symptomatic UTI by 1 to 2 years: antibiotics versus no prophylaxis compared with surveillance or no treatment (low certainty).

2 findings from 1 review

Interventions for primary vesicoureteric reflux 2019 · Cochrane Headline outcomes only
RR 0.77 [0.54, 1.09]
9 studies · 1667 participants
Low
Interventions for primary vesicoureteric reflux 2019 · Cochrane Headline outcomes only
RR 0.85 [0.4, 1.79]
3 studies · 943 participants
Moderate

Antibiotic prophylaxis vs placebo, no treatment or surveillance only

Febrile UTI by 1 to 2 years: antibiotics versus no prophylaxis · primary VUR

Antibiotic prophylaxis showed no clear difference in febrile UTI by 1 to 2 years: antibiotics versus no prophylaxis compared with surveillance or no treatment (low certainty).

1 finding from 1 review

Interventions for primary vesicoureteric reflux 2019 · Cochrane Headline outcomes only
RR 0.83 [0.56, 1.21]
9 studies · 1667 participants
Low

Antibiotic prophylaxis vs placebo, no treatment or surveillance only

Resolution of VUR · primary VUR

Antibiotic prophylaxis showed no clear difference in resolution of VUR after 1 to 2 years: unit of analysis (children) compared with surveillance or no treatment (low certainty).

1 finding from 1 review

Interventions for primary vesicoureteric reflux 2019 · Cochrane Headline outcomes only
RR 1.46 [0.71, 2.99]
3 studies · 262 participants
Low

Antibiotic prophylaxis vs placebo, no treatment or surveillance only

Adverse events · primary VUR

Antibiotic prophylaxis showed no clear difference in adverse events compared with surveillance or no treatment (moderate certainty).

1 finding from 1 review

Interventions for primary vesicoureteric reflux 2019 · Cochrane Headline outcomes only
RR 0.94 [0.81, 1.08]
4 studies · 1056 participants
Moderate

Antibiotic prophylaxis vs placebo, no treatment or surveillance only

Microbial resistance to prophylactic drug: unit of analysis (UTI) · primary VUR

Antibiotic prophylaxis probably leads to higher microbial resistance to prophylactic drug: unit of analysis (UTI) compared with surveillance or no treatment (moderate certainty).

1 finding from 1 review

Interventions for primary vesicoureteric reflux 2019 · Cochrane Headline outcomes only
RR 2.72 [1.85, 4]
6 studies · 259 participants
Moderate