Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

888 questions · 936 findings · 109 reviews

No studies found 196 · 20.9%GRADE not reported 88 · 9.4%Very low 226 · 24.1%Low 217 · 23.2%Moderate 152 · 16.2%High 57 · 6.1%

Topical antibiotics vs no topical antibiotic.

Allergic contact dermatitis · people presenting for surgery where healing of surgical wound planned to be by primary intention

It is very uncertain whether topical antibiotics changes allergic contact dermatitis compared with no topical antibiotic. (very low certainty).

1 finding from 1 review

Antibiotics vs no treatment or placebo on top of topical antibiotics

Ear pain (otalgia) or discomfort or local irritation · people (of any age) with CSOM

It is very uncertain whether systemic antibiotics changes ear pain (otalgia) or discomfort or local irritation ‐ measured at 1… compared with no treatment or placebo on top of topical antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs no treatment or placebo on top of topical antibiotics

Suspected ototoxicity · people (of any age) with CSOM

It is very uncertain whether systemic antibiotics changes suspected ototoxicity ‐ measured at 10 days to 3 weeks compared with no treatment or placebo on top of topical antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs no treatment or placebo on top of topical antibiotics

Resolution of ear discharge ‐ measured at 1 to 2 weeks · people (of any age) with CSOM

Systemic antibiotics showed no clear difference in resolution of ear discharge ‐ measured at 1 to 2 weeks compared with no treatment or placebo on top of topical antibiotics (low certainty).

1 finding from 1 review

Antibiotics vs placebo

Death at 6 months · adults with renal vasculitis for maintenance therapy

Antibiotics showed no clear difference in death at 6 months compared with placebo (low certainty).

1 finding from 1 review

Antibiotics vs placebo

Remission · adults with renal vasculitis for maintenance therapy

Antibiotics showed no clear difference in remission at one year compared with placebo (low certainty).

1 finding from 1 review