Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 20%Moderate 1 · 20%High 3 · 60%

Analgesic‐decongestant vs placebo

Adverse effects: all · otherwise healthy adults and children with common cold symptoms

Analgesic‐decongestant leads to higher adverse effects: all compared with placebo (high certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 1.62 [1.18, 2.23]
6 studies · 1797 participants
High

Analgesic‐decongestant vs placebo

Adverse effects: dry mouth · otherwise healthy adults and children with common cold symptoms

Analgesic‐decongestant showed no clear difference in adverse effects: dry mouth compared with placebo (low certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 1.43 [0.53, 3.83]
3 studies · 764 participants
Low

Analgesic‐decongestant vs placebo

Gastrointestinal adverse events · otherwise healthy adults and children with common cold symptoms

Analgesic‐decongestant showed no clear difference in adverse effects: gastrointestinal compared with placebo (high certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
RR 1.71 [0.97, 3.01]
5 studies · 1644 participants
High

Analgesic‐decongestant vs placebo

Adverse effects: dizziness, lightheadedness · otherwise healthy adults and children with common cold symptoms

Analgesic‐decongestant leads to higher adverse effects: dizziness, lightheadedness compared with placebo (high certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 2.86 [1.02, 8.01]
4 studies · 1287 participants
High

Analgesic‐decongestant vs placebo

Adverse effects: drowsiness, hypersomnia, lethargy, excessive sleepiness, and other central nervous system adverse effects · otherwise healthy adults and children with common cold symptoms

Analgesic‐decongestant showed no clear difference in adverse effects: drowsiness, hypersomnia, lethargy, excessive… compared with placebo (moderate certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 1.34 [0.76, 2.37]
5 studies · 1644 participants
Moderate