Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Oral Health

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No studies found 0 · 0%GRADE not reported 3 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Amoxicillin + clavulanate + SRP vs Tetracycline + SRP

Adverse events · Adults with aggressive periodontitis

Amoxicillin + clavulanate + SRP showed no clear difference in adverse events compared with tetracycline + SRP; GRADE not reported.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
The only included trial (Abu Fanas 1991) reported there were no adverse events.
1 study · 8 participants
GRADE not reported

Amoxicillin + clavulanate + SRP vs Tetracycline + SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

Amoxicillin + clavulanate + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with tetracycline + SRP; GRADE not reported.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -1.60 [-14.03, 10.83]
1 study · 8 participants
GRADE not reported

Amoxicillin + clavulanate + SRP vs Tetracycline + SRP

Probing pocket depth · Adults with aggressive periodontitis

Amoxicillin + clavulanate + SRP showed no clear difference in probing pocket depth compared with tetracycline + SRP; GRADE not reported.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.40 [-1.11, 0.31]
1 study · 8 participants
GRADE not reported