Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 1 · 50%Very low 0 · 0%Low 1 · 50%Moderate 0 · 0%High 0 · 0%

Amifostine vs no treatment/placebo

Nausea · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

Amifostine may leads to higher nausea (adverse effect) compared with no treatment/placebo (low certainty).

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
RR 2.60 [1.81, 3.74]
4 studies · 556 participants
Low

Amifostine 200 mg/m2 three times weekly vs Amifostine 200 mg/m2 five times weekly

Nausea · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

Amifostine 200 mg/m2 three times weekly showed no clear difference in nausea (adverse effect) compared with amifostine 200 mg/m2 five times weekly; GRADE not reported.

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
RR 0.64 [0.33, 1.25]
1 study · 60 participants
GRADE not reported