Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Drugs and Alcohol

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 66.7%Moderate 1 · 33.3%High 0 · 0%

Amantidine vs antidepressants

Leaving the study early · patients with the treatment of cocaine dependence

Amantidine showed no clear difference in dropouts compared with antidepressants (moderate certainty).

1 finding from 1 review

Dopamine agonists for the treatment of cocaine dependence 2015 · Cochrane Headline outcomes only
RR 0.86 [0.48, 1.53]
4 studies · 153 participants
Moderate

Amantidine vs antidepressants

Risk for at least one adverse event per patient · patients with the treatment of cocaine dependence

Amantidine showed no clear difference in adverse events as N of participants with at least one adverse event compared with antidepressants (low certainty).

1 finding from 1 review

Dopamine agonists for the treatment of cocaine dependence 2015 · Cochrane Headline outcomes only
RR 0.56 [0.18, 1.77]
2 studies · 44 participants
Low

Amantidine vs antidepressants

Abstinence · patients with the treatment of cocaine dependence

Amantidine may leads to lower abstinence (objective) N of subjects abstinent at the end of the study compared with antidepressants (low certainty).

1 finding from 1 review

Dopamine agonists for the treatment of cocaine dependence 2015 · Cochrane Headline outcomes only
RR 0.25 [0.12, 0.53]
2 studies · 68 participants
Low