Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Urology

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 2 · 28.6%Moderate 3 · 42.9%High 1 · 14.3%

Altered fraction schedules vs Conventional (standard) fractionation radiotherapy

Prostate cancer‐specific survival · clinically localized prostate cancer

Altered fraction schedules showed no clear difference in prostate cancer‐specific survival compared with conventional fractionation (low certainty).

1 finding from 1 review

Hypofractionation for clinically localized prostate cancer 2019 · Cochrane Headline outcomes only
HR 1 [0.72, 1.39]
8 studies · 7946 participants
Low

Altered fraction schedules vs Conventional (standard) fractionation radiotherapy

Late gastrointestinal RT toxicity ≥ Grade II RTOG/EORTC · clinically localized prostate cancer

It is very uncertain whether altered fraction schedules changes late gastrointestinal RT toxicity ≥ Grade II RTOG/EORTC compared with conventional fractionation (very low certainty).

1 finding from 1 review

Hypofractionation for clinically localized prostate cancer 2019 · Cochrane Headline outcomes only
RR 1.1 [0.68, 1.78]
4 studies · 3843 participants
Very low

Altered fraction schedules vs Conventional (standard) fractionation radiotherapy

Late genitourinary RT toxicity ≥ Grade II RTOG/EORTC · clinically localized prostate cancer

Altered fraction schedules showed no clear difference in late genitourinary RT toxicity ≥ Grade II RTOG/EORTC compared with conventional fractionation (moderate certainty).

1 finding from 1 review

Hypofractionation for clinically localized prostate cancer 2019 · Cochrane Headline outcomes only
RR 1.05 [0.93, 1.18]
4 studies · 3843 participants
Moderate

Altered fraction schedules vs Conventional (standard) fractionation radiotherapy

Overall survival · clinically localized prostate cancer

Altered fraction schedules showed no clear difference in overall survival compared with conventional fractionation (high certainty).

1 finding from 1 review

Hypofractionation for clinically localized prostate cancer 2019 · Cochrane Headline outcomes only
HR 0.94 [0.83, 1.07]
10 studies · 8243 participants
High

Altered fraction schedules vs Conventional (standard) fractionation radiotherapy

Metastasis‐free survival · clinically localized prostate cancer

Altered fraction schedules showed no clear difference in metastasis‐free survival compared with conventional fractionation (low certainty).

1 finding from 1 review

Hypofractionation for clinically localized prostate cancer 2019 · Cochrane Headline outcomes only
HR 1.07 [0.65, 1.76]
5 studies · 4985 participants
Low

Altered fraction schedules vs Conventional (standard) fractionation radiotherapy

Biochemical recurrence‐free survival · clinically localized prostate cancer

Altered fraction schedules showed no clear difference in biochemical relapse‐free survival compared with conventional fractionation (moderate certainty).

1 finding from 1 review

Hypofractionation for clinically localized prostate cancer 2019 · Cochrane Headline outcomes only
HR 0.88 [0.68, 1.13]
5 studies · 2889 participants
Moderate

Altered fraction schedules vs Conventional (standard) fractionation radiotherapy

Acute GU RT toxicity · clinically localized prostate cancer

Altered fraction schedules showed no clear difference in acute GU RT toxicity compared with conventional fractionation (moderate certainty).

1 finding from 1 review

Hypofractionation for clinically localized prostate cancer 2019 · Cochrane Headline outcomes only
RR 1.03 [0.95, 1.11]
4 studies · 4174 participants
Moderate