Findings

What do systematic reviews say?

8 questions · 8 findings · 3 reviews · Oral medicine and oral cancer

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No studies found 0 · 0%GRADE not reported 8 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Aloe vera vs placebo

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Aloe vera led to lower oral mucositis (moderate to severe) compared with placebo; GRADE not reported.

1 finding from 1 review

Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes
Median 28 days
RR 0.74 [0.58, 0.96]
2 studies · 119 participants
GRADE not reported

Aloe vera vs placebo

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Aloe vera led to lower oral mucositis (severe) compared with placebo; GRADE not reported.

1 finding from 1 review

Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes
Median 28 days
RR 0.13 [0.02, 0.97]
1 study · 61 participants
GRADE not reported

Aloe vera gel vs placebo

Physician Global Assessment (Thongprasom score) · People with erosive oral lichen planus

Aloe vera gel showed no clear difference in physician Global Assessment (Thongprasom score) compared with placebo; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
RR 2.64 [0.11, 61.54]
1 study · 45 participants
GRADE not reported

Aloe vera gel vs placebo

Primary outcome: partial clinical response · People with erosive oral lichen planus

Aloe vera gel led to higher partial response (>=50% clinical improvement) compared with placebo; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
RR 19.25 [2.83, 130.85]
1 study · 45 participants
GRADE not reported

Aloe vera gel vs placebo

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Choonhakarn 2008: no serious side-effects; 2 participants receiving aloe vera gel reported stinging and mild itching at lesions within the first week, symptoms spontaneously disappeared with…
1 study · 45 participants
GRADE not reported

Aloe vera gel vs placebo

Participant‐reported pain relief of 50% or greater · People with erosive oral lichen planus

Aloe vera gel led to higher pain (>=50% improvement in symptoms) compared with placebo; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
RR 6.16 [2.35, 16.13]
1 study · 45 participants
GRADE not reported

CMC spray / aloe vera gel / canola oil spray vs Mucin spray (and between each other)

Patient preference · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…

1 finding from 1 review

Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
No significant difference in patient preference between the treatments (Chi2 3.67, df=3; P = 0.30).
1 study · 123 participants
GRADE not reported

CMC spray / aloe vera gel / canola oil spray vs Mucin spray (and between each other)

Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…

1 finding from 1 review

Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
Momm 2005 (crossover, n=123): all four treatments significantly reduced dryness vs baseline (mean xerostomia score, scale 1 to 6: baseline 4.5 +/- 0.11; post-treatment aloe vera 3.7 +/- 0.11, CMC 3.8 +/- 0.12, canola…
1 study · 123 participants
GRADE not reported