Findings

What do systematic reviews say?

33 questions · 33 findings · 2 reviews

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No studies found 19 · 57.6%GRADE not reported 0 · 0%Very low 4 · 12.1%Low 8 · 24.2%Moderate 2 · 6.1%High 0 · 0%

Aldosterone antagonists vs ACEi or ACEi plus ARB

Death · proteinuric chronic kidney disease

The review found no eligible studies for this question.

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Aldosterone antagonists vs ACEi or ACEi plus ARB

Cardiovascular events · proteinuric chronic kidney disease

The review found no eligible studies for this question.

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Aldosterone antagonists vs ACEi or ACEi plus ARB

Doubling serum creatinine · proteinuric chronic kidney disease

The review found no eligible studies for this question.

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Aldosterone antagonists vs placebo or usual care

Death · proteinuric CKD

Aldosterone antagonists showed no clear difference in death compared with placebo or standard care (low certainty).

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
RR 0.58 [0.1, 3.5]
3 studies · 421 participants
Low

Aldosterone antagonists vs ACEi or ACEi plus ARB

AKI · proteinuric chronic kidney disease

The review found no eligible studies for this question.

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Aldosterone antagonists vs ACEi or ACEi plus ARB

Proteinuria · proteinuric chronic kidney disease

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 465 participants
Very low

Aldosterone antagonists vs ACEi or ACEi plus ARB

GFR · proteinuric chronic kidney disease

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Low

Aldosterone antagonists vs placebo or usual care

Cardiovascular events · proteinuric CKD

Aldosterone antagonists showed no clear difference in cardiovascular events compared with placebo or standard care (low certainty).

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
RR 0.95 [0.26, 3.56]
3 studies · 1067 participants
Low

Aldosterone antagonists vs placebo or usual care

Doubling serum creatinine · proteinuric CKD

Aldosterone antagonists showed no clear difference in doubling serum creatinine compared with placebo or standard care (low certainty).

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
RR 1.3 [0.69, 2.44]
2 studies · 875 participants
Low

Aldosterone antagonists vs placebo or usual care

AKI · proteinuric CKD

Aldosterone antagonists probably leads to higher AKI compared with placebo or standard care (moderate certainty).

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
RR 2.04 [1.05, 3.97]
5 studies · 1446 participants
Moderate

Aldosterone antagonists vs placebo or usual care

Proteinuria · proteinuric CKD

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
14 studies · 1193 participants
Very low

Aldosterone antagonists vs placebo or usual care

eGFR · proteinuric CKD

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 1144 participants
Low

Aldosterone antagonists vs diuretics

Kidney failure · proteinuric CKD

The review found no eligible studies for this question.

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found