What do systematic reviews say?

Aldosterone antagonists vs ACEi or ACEi plus ARB

Aldosterone antagonists showed no clear difference in hyperkalaemia compared with ACEi or ACEi plus ARB (low certainty).

• Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
  RR 1.62 [0.66, 3.95]
  2 studies · 500 participants
  Low