Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

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No studies found 2 · 33.3%GRADE not reported 0 · 0%Very low 4 · 66.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Agomelatine vs placebo

Incidence of SAD (modified ITT) · adults with a history of SAD

It is very uncertain whether agomelatine changes incidence of SAD (modified ITT) compared with placebo (very low certainty).

1 finding from 1 review

Melatonin and agomelatine for preventing seasonal affective disorder 2019 · Cochrane Headline outcomes only
RR 0.83 [0.51, 1.34]
1 study · 199 participants
Very low

Agomelatine vs placebo

Adverse events as N of participants with at least one adverse event subjective and objective · adults with a history of SAD

It is very uncertain whether agomelatine changes number of persons with at least one adverse event within a year compared with placebo (very low certainty).

1 finding from 1 review

Melatonin and agomelatine for preventing seasonal affective disorder 2019 · Cochrane Headline outcomes only
RR 1.06 [0.84, 1.34]
1 study · 225 participants
Very low

Agomelatine vs placebo

Severity of depression (SIGH‐SAD score) at the end of the study · adults with a history of SAD

1 finding from 1 review

Melatonin and agomelatine for preventing seasonal affective disorder 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 199 participants
Very low

Agomelatine vs placebo

Quality of life · adults with a history of SAD

The review found no eligible studies for this question.

1 finding from 1 review

Melatonin and agomelatine for preventing seasonal affective disorder 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Agomelatine vs placebo

Quality of interpersonal and social functioning · adults with a history of SAD

The review found no eligible studies for this question.

1 finding from 1 review

Melatonin and agomelatine for preventing seasonal affective disorder 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Agomelatine vs placebo

Number of participants experiencing at least one severe adverse event · adults with a history of SAD

It is very uncertain whether agomelatine changes number of persons with at least one severe adverse event within a year compared with placebo (very low certainty).

1 finding from 1 review

Melatonin and agomelatine for preventing seasonal affective disorder 2019 · Cochrane Headline outcomes only
RR 0.76 [0.17, 3.3]
1 study · 225 participants
Very low