What do systematic reviews say?

Afatinib vs chemotherapy alone

Afatinib leads to lower progression‐free survival compared with chemotherapy (high certainty).

• First‐line treatment of advanced epidermal growth factor receptor (EGFR) mutation positive non‐squamous non‐small cell… 2021 · Cochrane Headline outcomes only
  HR 0.42 [0.34, 0.53]
  2 studies · 709 participants
  High