Findings

What do systematic reviews say?

25 questions · 25 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 8%Low 12 · 48%Moderate 9 · 36%High 2 · 8%

Active NRT vs placebo ‐ rs1051730 ‐ non‐Hispanic white

Abstinence at end of treatment ‐ homozygous minor · people who smoke

Active NRT may leads to higher abstinence at end of treatment ‐ homozygous minor compared with placebo ‐ rs1051730 ‐ non‐Hispanic white (low certainty).

1 finding from 1 review

Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers 2017 · Cochrane Headline outcomes only
RR 2.18 [1.04, 4.58]
2 studies · 178 participants
Low

Active NRT vs placebo ‐ rs16969968 ‐ non‐Hispanic white

End of treatment · people who smoke

Active NRT showed no clear difference in end of treatment compared with placebo ‐ rs16969968 ‐ non‐Hispanic white (moderate certainty).

1 finding from 1 review

Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers 2017 · Cochrane Headline outcomes only
RR 1.38 [0.97, 1.98]
2 studies · 1127 participants
Moderate

Active NRT vs placebo ‐ rs16969968 ‐ non‐Hispanic white

End of treatment ‐ homozygous major · people who smoke

Active NRT showed no clear difference in end of treatment ‐ homozygous major compared with placebo ‐ rs16969968 ‐ non‐Hispanic white (low certainty).

1 finding from 1 review

Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers 2017 · Cochrane Headline outcomes only
RR 1.01 [0.77, 1.33]
2 studies · 449 participants
Low

Active NRT vs placebo ‐ rs16969968 ‐ non‐Hispanic white

End of treatment ‐ heterozygous · people who smoke

Active NRT leads to higher end of treatment ‐ heterozygous compared with placebo ‐ rs16969968 ‐ non‐Hispanic white (high certainty).

1 finding from 1 review

Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers 2017 · Cochrane Headline outcomes only
RR 1.85 [1.33, 2.59]
2 studies · 550 participants
High

Active NRT vs placebo ‐ rs16969968 ‐ non‐Hispanic white

End of treatment ‐ homozygous minor · people who smoke

Active NRT showed no clear difference in end of treatment ‐ homozygous minor compared with placebo ‐ rs16969968 ‐ non‐Hispanic white (low certainty).

1 finding from 1 review

Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers 2017 · Cochrane Headline outcomes only
RR 1.8 [0.45, 7.23]
2 studies · 128 participants
Low