Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

37 questions · 38 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 5 · 13.2%Low 17 · 44.7%Moderate 13 · 34.2%High 3 · 7.9%

Active NRT vs placebo ‐ DRD4 (exon 3 48 bp) ‐ non‐Hispanic white

6‐Month abstinence ‐ homozygous minor · people who smoke

It is very uncertain whether active NRT changes 6‐Month abstinence ‐ homozygous minor compared with placebo ‐ DRD4 (exon 3 48 bp) ‐ non‐Hispanic white (very low certainty).

1 finding from 1 review

Active NRT vs placebo ‐ rs1051730 ‐ non‐Hispanic white

Abstinence at end of treatment ‐ heterozygous · people who smoke

Active NRT probably leads to higher abstinence at end of treatment ‐ heterozygous compared with placebo ‐ rs1051730 ‐ non‐Hispanic white (moderate certainty).

1 finding from 1 review

Active NRT vs placebo ‐ DRD4 (exon 3 48 bp) ‐ non‐Hispanic white

End of treatment ‐ homozygous major · people who smoke

It is very uncertain whether active NRT changes end of treatment ‐ homozygous major compared with placebo ‐ DRD4 (exon 3 48 bp) ‐ non‐Hispanic white (very low certainty).

1 finding from 1 review

Active NRT vs placebo ‐ DRD4 (exon 3 48 bp) ‐ non‐Hispanic white

End of treatment ‐ heterozygous · people who smoke

It is very uncertain whether active NRT changes end of treatment ‐ heterozygous compared with placebo ‐ DRD4 (exon 3 48 bp) ‐ non‐Hispanic white (very low certainty).

1 finding from 1 review

Active NRT vs placebo ‐ DRD4 (exon 3 48 bp) ‐ non‐Hispanic white

End of treatment ‐ homozygous minor · people who smoke

Active NRT showed no clear difference in end of treatment ‐ homozygous minor compared with placebo ‐ DRD4 (exon 3 48 bp) ‐ non‐Hispanic white (low certainty).

1 finding from 1 review

Active NRT vs placebo ‐ rs1051730 ‐ non‐Hispanic white

Abstinence at end of treatment ‐ homozygous minor · people who smoke

Active NRT may leads to higher abstinence at end of treatment ‐ homozygous minor compared with placebo ‐ rs1051730 ‐ non‐Hispanic white (low certainty).

1 finding from 1 review