Findings

What do systematic reviews say?

9 questions · 9 findings · 2 reviews · Emergency and Critical Care

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No studies found 1 · 11.1%GRADE not reported 0 · 0%Very low 0 · 0%Low 5 · 55.6%Moderate 3 · 33.3%High 0 · 0%

Acetazolamide vs spironolactone 100 mg

Risk of high altitude pulmonary oedema · participants at risk of high altitude illness

1 finding from 1 review

Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 232 participants
Low

Acetazolamide vs spironolactone 100 mg

Risk of high altitude cerebral oedema · participants at risk of high altitude illness

1 finding from 1 review

Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 232 participants
Low

Acetazolamide vs placebo

Risk of high altitude pulmonary oedema · participants at risk of high altitude illness

1 finding from 1 review

Interventions for preventing high altitude illness: Part 1. Commonly‐used classes of drugs 2017 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 1138 participants
Moderate

Acetazolamide vs placebo

Incidence of high altitude cerebral oedema (HACE) ‐ not reported · participants at risk of high altitude illness

Acetazolamide showed no clear difference in incidence of high altitude cerebral oedema (HACE)‐ Follow‐ up: From… compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for preventing high altitude illness: Part 1. Commonly‐used classes of drugs 2017 · Cochrane Headline outcomes only
RR 0.32 [0.01, 7.48]
6 studies · 1126 participants
Moderate

Acetazolamide vs spironolactone 100 mg

Risk of acute mountain sickness · participants at risk of high altitude illness

Acetazolamide may leads to lower risk of acute mountain sickness compared with spironolactone (low certainty).

1 finding from 1 review

Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs 2018 · Cochrane Headline outcomes only
RR 0.36 [0.18, 0.7]
1 study · 232 participants
Low

Acetazolamide vs spironolactone 100 mg

Risk of adverse events ‐ not reported · participants at risk of high altitude illness

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Acetazolamide vs placebo

Incidence of acute mountain sickness (AMS)‐ Follow‐ up: From arrival to 24 hours later · participants at risk of high altitude illness

Acetazolamide probably leads to lower incidence of acute mountain sickness (AMS)‐ Follow‐ up: From arrival… compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for preventing high altitude illness: Part 1. Commonly‐used classes of drugs 2017 · Cochrane Headline outcomes only
RR 0.47 [0.39, 0.56]
16 studies · 2301 participants
Moderate

Acetazolamide vs placebo

Adverse events: Paresthesias‐ Follow‐ up: From arrival to 24 hours later · participants at risk of high altitude illness

Acetazolamide may leads to higher adverse events: Paresthesias‐ Follow‐ up: From arrival to 24 hours… compared with placebo (low certainty).

1 finding from 1 review

Interventions for preventing high altitude illness: Part 1. Commonly‐used classes of drugs 2017 · Cochrane Headline outcomes only
RR 5.53 [2.81, 10.88]
5 studies · 789 participants
Low

Acetazolamide vs placebo

Side effects or other adverse events · participants at risk of high altitude illness

Acetazolamide may leads to higher adverse events: side effects‐ Follow‐ up: From arrival to 24 hours… compared with placebo (low certainty).

1 finding from 1 review

Interventions for preventing high altitude illness: Part 1. Commonly‐used classes of drugs 2017 · Cochrane Headline outcomes only
RR 2.19 [1.36, 3.53]
1 study · 400 participants
Low