Findings

What do systematic reviews say?

8 questions · 8 findings · 3 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 12.5%Low 2 · 25%Moderate 4 · 50%High 1 · 12.5%

Acetaminophen vs control or placebo medications

Acute postoperative pain at 12 hours (Score 0 to 10, VAS or NRS Scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 332 participants
Moderate

Acetaminophen vs control or placebo medications

Acute postoperative pain at 24 hours (Score 0 to 10, VAS or NRS Scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 459 participants
High

Acetaminophen vs control or placebo medications

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 202 participants
Very low

Acetaminophen vs control or placebo medications

Acute postoperative pain 0 to 6 hours (Score 0 to 10, VAS or NRS Scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 332 participants
Moderate

Tramadol in combination with acetaminophen vs NSAIDs

Pain · patients with osteoarthritis

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 226 participants
Moderate

Tramadol in combination with acetaminophen vs other opioids

Pain · patients with osteoarthritis

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 130 participants
Low

Tramadol in combination with acetaminophen vs placebo

Pain · patients with osteoarthritis

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 614 participants
Moderate

Preoperative paracetamol (acetaminophen) vs placebo

Postoperative pain (dichotomous measure: parent report of presence of pain-related behaviours) · Children and adolescents having dental treatment under local anaesthetic (restorative and extraction treatments)

Preoperative paracetamol (acetaminophen) showed no clear difference in postoperative pain (dichotomous measure: parent report of presence… compared with placebo (low certainty).

1 finding from 1 review

Preoperative analgesics for additional pain relief in children and adolescents having dental treatment 2016 · Cochrane All outcomes
Mean 6.5 hours
RR 0.81 [0.53, 1.22]
2 studies · 100 participants
Low